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Muh Muh Muh My Corona (virus)

Discussion in 'Sports and News' started by Twirling Time, Jan 21, 2020.

  1. wicked

    wicked Well-Known Member

    To the smart types who know much more than I do: if we keep getting boosters, will that lower their efficacy? Especially if there is no change in the formula. At least with the flu shot, the mix changes yearly.
     
  2. Twirling Time

    Twirling Time Well-Known Member

    I had my boost so recently, that I have to wait until after Memorial Day to get El Cuatro.

    My last one timed perfectly with Omicron, so I expect my next one will time perfectly with Pi.
     
  3. Michael_ Gee

    Michael_ Gee Well-Known Member

    Research continues on altering covid vaccine formulas to match with variants. But it's way early in the experimental stages.
     
  4. Twirling Time

    Twirling Time Well-Known Member

    Basically we never had a vaccine for the "common cold" until now. Mainly because this "common cold" can kill you and we mobilized against it.

    The way I look at it, any one of the other 739 cold viruses out there circulating could mutate and wipe out humanity.

    But surprise, they haven't.

    It doesn't violate common sense that Darwinism is alive and well in the virus world as well. The virus that doesn't kill its host has the best and longest chance to propagate itself.
     
    maumann and 2muchcoffeeman like this.
  5. Azrael

    Azrael Well-Known Member

  6. MisterCreosote

    MisterCreosote Well-Known Member

    I don’t see why it would. The mRNA vaccines just deliver instructions (as opposed to the flu shot, which targets individual strains of the virus itself). And no vaccine decreases in effectiveness based on the number of doses you get.

    If anything, a highly vaccinated public could hasten a mutation that evades the vaccine, but that will happen anyway, as we saw with Omicron.
     
  7. Octave

    Octave Well-Known Member

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  8. The Big Ragu

    The Big Ragu Moderator Staff Member

    The mechanism of delivery for an mRNA vs. an attenuated virus vaccine is different, but I'm not sure why you'd say that it doesn't target "individual strains." The spike protein in the mRNA vaccine was taken from the original SARS-CoV-2 strain. Since then, new variants with different spike proteins have developed. The mRNA vaccines instruct your cells to produce that spike protein, which your immune system then produces antibodies to fight. There is still enough overlap between the spike proteins in the various strains that we are still getting some immunity from those vaccines, but its efficacy in preventing sickness at all is not as good as it was against the specific variant the vaccine was originally targeting. It's why in the fall before this hopefully becomes a seasonal thing, there is a good chance that we'll be lined up for new vaccines that better target the spike proteins of the newer variants that became more prevalent. It's true that the mRNA is just the delivery mechanism, but the mechanism of action -- in the case of these vaccines, the spike protein it targets -- does target a very specific, or individual, strain of virus.
     
  9. wicked

    wicked Well-Known Member

    Thank you to those who explained it to me like a third-grader.
     
  10. MisterCreosote

    MisterCreosote Well-Known Member

    First, only the nasal spray vaccine is attenuated. Flu shots are not — they’re dead (inactivated).

    What I mean by “individual strains” is literally that — the flu vaccines include the four predominant, circulating strains, and those four can change in any given year. And protection against, say, California H1N1 would provide NO protection against other strains, not even against severe illness and hospitalization.

    The exact opposite is true of the mRNA COVID vaccines so far. They have been damn-near equally effective at preventing hospitalization and death against all the strains we’ve seen so far.

    That’s not to say we won’t need yearly or bi-yearly shots going forward. I’ll bet we will. It only makes sense to be that vigilant.
     
  11. Sam Mills 51

    Sam Mills 51 Well-Known Member

    Shanghai has been a mess for a week. Shutdowns. Supply issues. Truck drivers trying to get supplies in bring tested, slowing down an already-too-slow supply line. People upset about being locked down.

    The panic factor is climbing quickly among both citizens and government employees. Children and parents suddenly being allowed to quarantine together after the government backed down after being pressured.

    Xi trying to give himself another five-year at the helm. Hmm … sounds like some place many of us know two years ago.
     
  12. Michael_ Gee

    Michael_ Gee Well-Known Member

    I read on Twitter yesterday a thread from a woman in Shanghai who said that the one thing that could break the contract between the Communist Party (and Xi, obviously) was if people couldn't get food.
     
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