Damn you, message length limit ...
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For Better or For Worse: For worse. Once a fairly endearing family strip, mushiness and self-righteousness has ruled in the land of the Pattersons, where everyone who doesn't share a bloodline with the core family fails at life. Cornball jokes, cornball morality tales. A long way from the "Lawrence is gay" and "Farley dies saving April's life" storylines, the latter being one of the better things I've ever seen in the funnies.
Speed Bump: Trying to fill the Far Side hole, literally and figuratively. It only succeeds on the first.
Pardon My Planet: It is what it is; above-average one-hit jokes.
Beetle Bailey: Enduring but never terribly good.
Dilbert: Still has its moments, but probably better off in the business section where it's a chance of pace instead of in the middle of general-purpose strips.
Cathy: Zut alors, this sucks. I guess you have to admire Guisewite in that she doesn't fundamentally change the strip because the main character's getting married, but the problem is, the strip is in need of it. But then I don't obsess over buying bathing suits, so I'm not the target demo.
Zits: Best comic out there. Funny, at times charming and thoughtful, rarely misses. Great writing and character development really hits it out of the park. Swiss-watch timing.
Frank and Ernest: The biscuit child of Far Side, Broom Hilda and a monochrome computer monitor.
Mother Goose and Grimm: The biscuit child of all of Frank and Earnest's biscuit parents, plus a retarded Get Fuzzy.
Curtis: Who doesn't want to see someone beat the crap out of that jackoff Barry? I always dig the Sunday strips where they make fun of the church ladies' hats.
Rex Morgan, M.D: No comment because serial strips bore me (though I try to keep an eye on Apartment 3-G online for reasons I can't quite explain).
Get Fuzzy: A close second to Zits. The throwaway observational humor and cutdowns in the first panel usually rate tons better than the money shot for 90 percent of the strips out there. Timing is impeccable and the writing flows like Courvoisier down an icy hill.
Judge Parker: See Rex Morgan.
Hi & Lois: Everything Zits and Fox Trot is, only in heck. Jokes are telegraphed and rarely worthy of anything but an eyeroll. Characters are caricatures, and the ones you see at the theme park, not the cool arty black-and-white ones at the trendy bistro in town.
Dennis the Menace: Get a copy of the first two bound volumes of Dennis and marvel at how much more of an asshole he was back in the day, what a lecherous would-be womanizer the dad was, and what a rack the mom had. Today's hackeneyed version is a slap in the face to the original.
Jump Start:Escapist panels setting up or responding to everyday occurances are a nice touch, and the writing is fine. I like it.
Sally Forth: Someone, anyone, wipe the smirk off Sally's face. And deliver a Pedigree to Hilary. The author hangs out on the bulletin board of a  pretty decent comic blog (www.joshreads.com [it's not me]) and by reading between the lines, you can tell that this is a sanitized, corporate-approved version of his vision.
The Family Circus: Who keeps reading this shirt? Ida Know! Not Me! Probably the best comic to which you can make sarcastic comebacks or create better punchlines, as the late, lamented Dysfunctional Family Circus taught us.
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Doonesbury: I like the character development. The political humor, not so much (though admittedly as a conservative I have a skewed vision — it's scads better than Mallard Fillmore, though).
Pluggers: You Might Be a Redneck with interactivity.
I'd like them to get Prickly City, which I get on Yahoo every day; it's a conservative-leaning strip, but it's handled with a Bloom County-esque flair that far surpasses the blunt and unironic Mallard Fillmore. I think they used to get the Boondocks, but they may have replaced it once it went on hiatus; it was just as well, it lost a lot of zing off the fastball in recent years and went from being a sharp-tongued, deep polemic from the eyes of a young aware black kid to little more than a paid advertisement for the DNC. We don't get Snuffy Smith, Luann or Marvin, and believe me, I'm not burning the phone lines up for any of 'em.